City are favoured to win because of the way they are blitzing their opposition, but it must be remembered Antonio Conte's Chelsea are the title holders and are notoriously hard to beat - especially at home.
Last season, Chelsea who went on to win the league, did the double over Manchester City.
The Spaniard juxtaposed Jose Mourinho's side with Premier League champions Chelsea and Tottenham Hotspur, describing them as teams that "like to play football" while seemingly criticising United's approach.
Chelsea, now third in the Premier League table on 13 points, are gunning to step up with a win against Manchester City who are atop the on 16 points.
Conte was publicly critical of the decision to schedule Chelsea's match against City on Saturday rather than Sunday, ensuring that he could only prepare his team for one day at Cobham after Wednesday's comeback victory over Atletico Madrid in the Champions League.
The striker suffered a fractured rib in a vehicle accident in Amsterdam on Friday night, and it is believed that he will need two to four weeks of recovery before returning to play.
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"Travelling to Stamford Bridge, I don't see them changing anything about the way they play and that makes for a hugely interesting game".
"I am not surprised, it is normal when you have a good run then when the press speak about you". "I have a lot of respect for my neighbours".
"I think the players have to rest mentally and physically". I want my players to have fun.
Antonio Conte's side have one of the best defenses in the league, and will look to frustrate City's high-power attack, but there's also a good chance we see Eden Hazard start his first league game of the season in support of Alvaro Morata in Chelsea's front three.
Conte's Chelsea sit third in the table behind the Manchester clubs. You need a bit of time to adapt but I'm pleased for him as he's playing very well and scoring.
"It's very important for us before the global break to take the three points".