The Trump National Doral resort in Miami, however, is "fine, we're still open, and normal", according to its front desk.
Sauve said 42 pet owners surrendered their pets to animal care on Friday, explaining they could not take them along to shelters or higher ground - a hard but much more humane solution as the storm gets closer.
Winds of 140mph are likely to test a boast from Mar-a-Lago staff that it can withstand any storm.
The mansion's walls are 3-feet thick, anchored by steel and concrete beams embedded into coral rock.
Woman gives birth alone at home during Hurricane Irma
Hurricane Irma hit the Florida Keys this morning as a Category 4 storm with 130 miles per hour maximum sustained winds. The first hurricane-force winds arrived in the Keys Saturday night, bending palm trees and bringing driving rains.
Mr Senecal added: 'That house ain't going nowhere. That construction, stop and think about it.
In addition to Mar-a-Lago, the Trump International Golf Club and the Palm Beach and Trump National Golf Club are also closed, as numerous Trump properties take precautions against the storm, a spokesperson for the Trump Organization said in a statement on Friday.
Trump already has spent seven weekends at the resort since his inauguration, mingling with the club's 500 members, who pay $14,000 in annual fees. Trump reportedly collected $17 million in damages from a 2005 hurricane there and complained of water damage to a basement.
Representatives from the Miami, West Palm Beach, and Palm Beach properties did not immediately return ABC News' request for comment, and the general manager of the Jupiter property declined to comment.
Florida State Attorney Dave Aronberg said people who left their pets to ride out the storm will be found.