This was the first of Newton's four touchdown passes on the night.
With All-Pro tight end Greg Olsen nearing his return and wide receiver Devin Funchess (five receptions, 95 yards, two touchdowns) continuing to improve in his third campaign, the Panthers may finally have an offense to go alongside their (usually) strong defense heading down the stretch.
Carolina had had its share of games where it rode the shoulders of its defense to a victory.
"Just bring home a win on a Monday night", said fan, Alisha Midgett.
And if you know anything about Newton and his love of the biggest stage, you knew it would be.
The Dolphins lost to the Carolina Panthers 45-21 as the team never led in the game.
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Newton's heroics helped the Panthers rewrite a chunk of their offensive record book. Carolina racked up 548 yards of total offense, besting their season average by over 230 yards. Their previous high was a 543-effort in a 34-29 loss at Chicago in 2011. "Don't disappoint the city on a Monday night". "It's a really good time to come out on a Monday night football game".
Newton improved to 5-1 on Monday nights, during which he's tossed 15 TDs against only four interceptions.
The Panthers converted on Newton's 7-yard touchdown pass to tight end Ed Dickson at the 19-second mark.
It was the second-longest run of Newton's career, behind only a 72-yard scamper in 2012.
As Miami attempts to find a new running back in the wake of the Jay Ajayi trade, Kenyan Drake rushed for a score on seven carries, finishing the night with 82 yards. His running helped set up a Cameron Artis-Payne 12-yard run to paydirt to put the Panthers up 31-7. This marked the first time in franchise history Carolina has run for 200-plus yards in back-to-back games - last week the Panthers ran for 201 yards against Atlanta.