The Ravens are expected to place Smith on injured reserve this week.
According to Adam Schefter of ESPN, Smith has been suspended four games for violating the league's PED policy, and has withdrawn his appeal.
Before the injury, Smith was having one of his best seasons as a professional.
Winter storm warnings, advisories issued for most of the Northland
To the southeast, the Twin Ports and Interstate 35 corridor are expected to see 1 to 3 inches of snow. The storm system moves out of the Rockies into the Plains Monday morning with snow, wind and rain.
After suffering a season-ending Achilles injury in a Week 13 win against the Detroit Lions, Smith will withdraw his appeal and immediately begin serving the suspension.
The Baltimore Sun reported Smith and the team were made aware of the pending suspension last week. The seven-year veteran has missed several practices, but started all 12 games and is second on the team with three interceptions.
Rookie first-round pick Marlon Humphrey will replace Smith in the starting lineup Sunday night, when Baltimore plays at AFC North-leading Pittsburgh. Humphrey came in for Smith against the Lions on Sunday and was quickly beat for two deep balls by Marvin Jones, however, Humphrey did come up with an interception in the game. Smith, who was drafted by Baltimore in the first round back in 2011, also has 26 total tackles this season.