The Bel-Air fire ravaged Bel-Air and Brentwood over two days, destroying more than 500 homes - including those of some celebrities. It began at 3:43 a.m. PT Monday, the Los Angeles County Fire Department said.
A firefighter suffered neck burns and was treated at a hospital, authorities said.
The fire was burning in the same general area as the devastating Bel Air Fire of 1961.
The new fire was situated in the Sepulveda Pass, where the San Diego (I-405) Freeway cuts a path through the mountains to connecting West Los Angeles and the San Fernando Valley.
Upton of Cal Fire said she can not remember any time when so many wind-driven fires were burning at the same time this late in the fire season.
"With winds like these, it can be anything", Los Angeles Mayor Eric Garcetti said.
For the first time, the Los Angeles Fire Department Thursday plans to deploy drones to help coordinate its battle against a pair of wildfires threatening homes in the city.
US Panel Locks in Final Tariffs on Canadian Softwood Lumber
The disagreement centers on the fees paid by Canadian lumber mills for timber cut largely from government-owned land. The Canadian government has denied taking actions to prop up the industry to the detriment of the USA industry.
Residents are being asked to evacuate the area south of Mulholland, east of the 405, north of Sunset and west of Roscomare.
Mandatory evacuation orders were also issued.
LAFD Chief Ralph Terrazas said red flag conditions are expected to remain in effect through the rest of the week, with gusting Santa Ana winds presenting a continuing danger of rapidly spreading blazes.
On Wednesday firefighters managed to stop the spread of a wildfire that has destroyed homes near the world-famous Getty museum in Los Angeles.
It is not clear if the outages may affect Long Beach or other areas. A full list of closed schools is available at www.lausd.net.
UCLA canceled classes Thursday, and Santa Monica College and all schools in the Santa Monica-Malibu school district were closed. It was unclear if those campuses would reopen on Friday. By noon Wednesday it had scorched 14,000 acres and forced the evacuation of 110,000 people.
The fire resulted in major changes in local fire safety laws, including brush clearance rules and an eventual city ban on wood shingle roofs.