In recent years, 63-year-old Ms Winfrey has used her star power to endorse Democratic presidential candidates such as Barack Obama in 2008 and Hillary Clinton in her campaign against Donald Trump in 2016.
The famed talk show host, actress, producer, and humanitarian especially spoke about the #MeToo movement and said, "I want all the girls watching here and now to know that a new day is on the horizon!"
Her partner, Stedman Graham, later told the Los Angeles Times: "It's up to the people". They're part of the world of tech and in politics and business.
House Minority Leader Nancy Pelosi, D-Calif., noted that Winfrey, like Trump, lacks any kind of governing experience. She paid tribute to the press and the importance of press freedom as it faced new pressures from the President. "I love red", she told Fox News.
Last fall Winfrey dismissed the notion of running for president.
Asked about a potential Winfrey candidacy in 2020, a White House spokesman said, "We welcome the challenge, whether it be Oprah Winfrey or anybody else".
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Recounting how Mrs Taylor, whose attackers were never prosecuted, had died last month shortly before her 98th birthday, Winfrey said: "She lived as we all have lived, too many years in a culture broken by brutally powerful men".
Axios reporter Jonathan Swan tweeted that she had "raised eyebrows" with the tweet supporting Oprah's words.
By the end of the night, the Internet was praising her as the queen she is and calling for her to run for president. It wasn't really us and even if it was, endorsing someone for president should not be taken as political. Let's all come together, women & men, & say #TIMESUP!
Trump's job approval rating sat at just 32 percent in December, according to an Associated Press-NORC poll. He has also been accused by multiple women of sexual misconduct, though he has vehemently denied the allegations. But, the drumbeat for her to make a presidential run was well underway. "I hope [Plummer] can do a Southern accent, because Kevin Spacey sure couldn't", he said.
Perhaps, it is time Ivanka stops talking about things she does not believe in.
If the queen of TV talk does decide to heed the calls, it's likely to cause serious headaches for Donald Trump - who once endorsed her for office. "I know it's hard but #TIMESUP for your dad too", Tara Strong wrote. "Their time is up", said Winfrey.
May tells bankers they are a priority for Brexit amid job warnings
The meeting focused on Brexit , how to make Britain a more attractive place for financial services and how to rein in executive pay, three people briefed on the talks said.