Vanpelt died at the scene while his passenger, 43-year-old Ronald Higgins of Dade City, was taken to Osceola Regional Medical Center in critical condition, according to a crash report.
All three northbound lanes remain blocked until about 1 p.m. Drivers were encouraged to use USA 1 as an alternate route and allow extra time.
The Florida Highway Patrol is working a fatal crash on I-95 northbound north of State Road 207.
In addition, troopers reported a second crash at 11:40 a.m. involving two vehicles located northbound at SR 206 on I-95.
Backlash continues over President Trump's reported comments
There was no mention at that time of the language that sources said Trump had used, details of which were soon leaked. The president said at the White House that "love was central" to the slain civil rights leader.
The roadway was closed for a time as crews dealt with the crash, but FHP reports the interstate is now back open.
Deputies warn that traffic was backed up for miles and drivers need to use caution once the road reopens.
Pontecorvo was traveling in the outside northbound lane of the highway when, for reasons that were still under investigation, she failed to stop and collided with the back of the truck.
Last year, 44 people were killed in 41 crashes.