A Winter Weather Advisory is in effect for the Piedmont Triad and will last until noon Thursday.
Snowfall on Wednesday is expected to be the heaviest in North Carolina - Raleigh could get up to 6 inches - and New England, where Boston also could see around 6 inches.
Winter weather advisories covered most of Alabama and much of Georgia as well, and several school districts across the region canceled classes for Tuesday.
Even though temperatures across Texas were in the 60s and 70s yesterday, a cold front courtesy of Winter Storm Inga moved in overnight, covering much of the Lone Star State in freezing rain, ice and even a little bit of snow.
In Georgia, two people were fatally struck by a auto that slid on an ice patch near Macon, local media said.
Houston-area officials urged people to stay off the roads.
Flight disruptions were piling up late Wednesday as nearly 1,700 arrivals and departures were cancelled or delayed at Hartsfield-Jackson International Airport in Atlanta, Ga., with hundreds of other delays and cancellations reported at airports in New Orleans, La., Houston, Charlotte, N.C. and Raleigh, N.C.
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Weather.com is projected snow to continue from Georgia into SC with rain changing to snow in the western Carolinas.
"You want to just barely touch the brakes in that situation", he said. Forecasters said frostbite would be a threat in north Georgia because of below- zero (-18 Celsius) wind chills.
In storm-hit North and SC, more than 32,000 homes and businesses were without power by Wednesday afternoon, utilities data showed.
More than 9 inches (23 cm) of snow has fallen in Durham, North Carolina since Monday, with 7 inches (18 cm) or more measured at various locations across southern Virginia, the NWS said.
"Traffic is moving along, but on side roads and residential streets it's pretty slick", said Brown, who works at Holaway's Food Market.
Wednesday Afternoon: Snow tapering off to flurries by early afternoon with highs in the mid 30's.
In addition to the snow, more than 40 million people are under wind chill alerts from the northern Plains, such as western Montana, North Dakota and Minnesota, down to portions of Texas and Louisiana.