'We will need to be very tough and relentless in our defence to keep the pressure on this Scottish team.
Hughes has made a swift recovery from knee ligament damage, and is fit to start after a conditioning crash-course in England camp over the past few weeks.
'Nathan Hughes has worked hard on his fitness.
"As always our supporters will play a vital role throughout the match and we're delighted to be back at Murrayfield with the backing of our home fans".
Lock Joe Launchbury will make his 50th test appearance. He replaces Sam Simmonds.
Russell has retained his place in Gregor Townsend's starting line-up despite an inauspicious start to the Championships, struggling against Wales and eventually being replaced at fly-half for the victory over France. We watched the game a year ago and we've watched their games over the last few weeks and to generate that line speed, especially off first phase, you have to make sure you stay 10 metres back off line-outs before the ball is delivered and you don't get beyond the back foot of the ruck in phase play. "He is a quality player and we don't want him to have a sniff at all".
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Safe: Russell kept his place.
"Russell is going to be under incredible heat from the England back row and the backs", he told BBC Radio 5 live's Rugby Union Weekly podcast.
"But I don't think we have to score tries to win, it just means our defence is going to have to be pretty top notch".
"My ball-carrying has improved a lot under Eddie, and I'm more of an impact player, I want to add as much impact as I can for my team whether it's through a carry or tackle, or if it's getting a maul going forward - that is my job", he explained.
"It's definitely something we have highlighted to our players", said Townsend.
England have not lost in their last 10 internationals against Scotland dating back to 2008 and sit level with Ireland on nine points at the top of the Six Nations standings after two matches.