Pogba has returned to training after missing Saturday's 2-1 Premier League victory over Liverpool.
Mourinho's men are aiming to qualify for the quarter-finals of Europe's elite club competition after playing out a goalless draw with the Spanish side in the first leg last month.
The Portuguese had told reporters on Pogba's possible availability following a win over Liverpool: "I don't know".
Mourinho also confirmed that Daley Blind and Marcos Rojo remain out while Ander Herrera is still working his way back to fitness after aggravating a hamstring injury.
This clash ought to be the one in which everything is in his favour, and if Sanchez gets it right then former United star Lou Macari agrees he could make all the difference going forward in the competition. The buzz in the stadium will be an obvious plus for United on Tuesday night but apart from that, the Liverpool match provided a glimpse of how Manchester United can adjust without Paul Pogba.
Kagiso Rabada suspended for two Tests, to miss remainder of Australia series
With Smith's dismissal, Rabada was seen as brushing the Australian skipper's shoulders after dismissing him in the first innings. The key seemed to be Mitchell Marsh, the last member of Australia's top six, who was unbeaten on 39 at the start of play.
Manchester United will put themselves in contention for Champions League glory if they overcome Sevilla, according to Jose Mourinho - even though they are not one of the best in teams in the tournament.
On the other hand, Sevilla are coming off a 0-2 loss against Sevilla the last time out. It was only when Mane and Firmino dropped deeper in the second half that Liverpool found a higher tempo, though too often a distance from goal.
Martial exercised normally with his teammates after having missed Manchester United's last two wins against Liverpool and Crystal Palace. There were, however, wins against both Malaga and Athletic Bilbao in between that sandiwch of defeats.
United host their LaLiga opponents on Tuesday with the last-16 tie all square at 0-0 following a drab first leg at the Ramon Sanchez Pizjuan. Knowing they conquered just two points on the road during the Champions League's group stage, we might see a cautious Sevilla here. Will they pull the upset, or will United hold on? Considering that with Sevilla's cautious approach on the road, The Red Devils have a good chance to sneak into the CL's quarterfinals for the first time since the 2013-14 season. Nemanja Matic struck home a gorgeous half-volley in added time for a remarkably good comeback. Mind you that all winnings are paid in free bets and that there is additional £100 in free bets waiting for you on your next 5 deposits.