Trump said the strikes were meant to deter the use of chemical weapons like the attack on civilians in the Syrian town of Douma last week, and that the US was prepared to continue the attacks until the Syrian regime stops using chemical weapons.
Macron spoke with Russian President Vladimir Putin on Friday, hours before the Western missile strikes.
France is urging Russia to join in renewed peace efforts after Western missile strikes on Syria aimed at punishing Bashar Assad for an alleged chemical attack, while the Syrian leader was said to have appeared unfazed Sunday in a meeting with Russian politicians.
Russian Federation also calls it "fabricated".
"Just deterring this act with a few airstrikes and not looking at the consequences for Syria wouldn't be a fully fleshed-out action", said another senior administration official.
Russian Federation and Syria have said there was no evidence of a chemical weapons attack.
Since 2015 France has carried out air strikes against Islamic State in Syria as part of allied forces linked to the USA -led coalition, conducting about 5 percent of total coalition air missions.
"We warned about this long ago", he said.
At the United Nations meanwhile, diplomats were mulling a draft resolution put forward by Sweden and obtained by AFP, that would dispatch a "high-level disarmament mission" to rid the country of chemical weapons "once and for all".
"This is grotesque, it is a blatant lie, it is the worst piece of fake news we've yet seen from the Russian propaganda machine", Pierce told reporters.
U.S. weighs strong response to Syria attacks despite risk of Russian Federation clash
Putin spoke to Israeli Prime Minister Benjamin Netanyahu on Wednesday and urged him to do nothing to destabilise Syria . Not for decades, they said, had the United States and Russian Federation come so close to a direct military clash.
Wednesday: Russia's Foreign Minister Sergei Lavrov said Russian military inspectors found no evidence of a chemical attack.
Tayyip Erdogan, president of Syria's neighbour Turkey which is also in North Atlantic Treaty Organisation, said on Friday he had spoken by phone with Trump and Putin and told both that increasing tension in the region was not right.
Meanwhile, Western allies of the USA came out in support of the strikes.
The investigators, who are only mandated to determine if chemical weapons were used and not who used them, were expected to start their investigations into the Douma incident on Saturday, the Netherlands-based agency said.
"This will reduce the regime's ability to further attack the people of Syria with chemical weapons", he said.
In Geneva, U.N. war crimes investigators condemned on Friday the suspected use of chemical weapons in Douma and called for evidence to be preserved with a view to future prosecutions.
On the ground in Syria, rebels in Eastern Ghouta surrendered their heavy weapons and their leader left the enclave, signalling the end of one of the bloodiest assaults of the seven-year war and a major win for the Assad regime.
U.S., French and British air forces conducted a massive missile strike on military and civilian infrastructure in Syria from 3:42 to 5:10 Moscow time (0042-0210 GMT), the statement added.
Bolton has called the Syrian civil war a "sideshow" and said he is much more concerned about Iran's role there than about whether Assad remains in power.