"This morning at 6:41 a.m. the Asheville Police Department responded to the home of actor Harry Anderson where he was found deceased", Asheville PD's Public Affairs officer Christina Hallingse told THR.
Asheville Police told the station that no foul play was suspected in his death.
However, it was his starring role as Judge Harry T. Stone on NBC's Night Court that made Anderson a household name.
Anderson's other well known roles include eight appearances on Saturday Night Live and a recurring role as con man Harry "The Hat" Gittes on Cheers. The CBS series was inspired by the work of columnist Dave Barry.
Anderson also appeared on "Cheers" and starred in his own sitcom, "Dave's World", which ran from 1993 to 1997.
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Anderson is survived by his wife Elizabeth Morgan and two children from his first marriage to Leslie Pollack. They named the character Harry so I'd keep in mind to react when someone said my name.
Friends and admirers took to Twitter to remember Anderson and offer their condolences. "He was a one of a kind talent who made millions so happy", filmmaker Judd Apatow wrote.
Night Court co-star Markie Post, who played Christine Sullivan, wrote, "I am devastated".
"The last time Harry Anderson played Comedy Magic Club, I opened for him", actress Cristela Alonzo wrote. He was just wonderful.
Although he had a long television career, Anderson said he never came to consider himself an actor.