The Suits actress chose a modest white bridal gown designed by Givenchy's Clare Waight Keller.
After their joyful kiss on the steps, the couple - now the Duke and Duchess of Sussex - then set off on a procession through the streets of Windsor in an open carriage drawn by four Windsor Grey horses.
The presence of Prince Harry's mother, Princess Diana, was subtly felt at her son's wedding to the American actress Meghan Markle, more than two decades after she was killed in a vehicle crash in Paris. She smiled broadly as the Archbishop of Canterbury Justin Welby declared them husband and wife.
The wedding was a global event, thanks to Harry's status as a senior British royal and Markle's celebrity after starring on the USA television series "Suits" for seven years.
Chopra was one of the first few persons to know about her friend's engagement to Prince Harry. As Charles and Meghan drew close to the altar, Harry said: "Thank you, Pa". They cheered and screamed and sighed as the newlyweds passed by. Some had camped out for days to get the best possible spot, while others rose before dawn to make their way to Windsor amid a party atmosphere. Oprah Winfrey, Idris Elba, Elton John, George and Amal Clooney, Serena Williams, James Corden and David and Victoria Beckham all watched from rows of seats in the Gothic masterpiece that is St. George's Chapel at Windsor Castle.
The Queen, wearing a lime silk dress, was accompanied by Prince Philip.
Meghan and Harry didn't share their first kiss after exchanging their vows, instead waiting until they exited the chapel to share a sweet smooch in front of the thousands of fans waiting outside. Prince Charles, the groom's father, will walk her down the aisle after Markle's own father became too ill to come.
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Also present were cast members from "Suits" - the legal drama in which she made her name - including Abigail Spencer, Sarah Rafferty, Gina Torres and Gabriel Macht.
It made for a striking image: Markle, in a fairy-tale gown, confident and overjoyed, walking toward the man of her dreams.
St. George's Chapel was decorated with white roses, the favorite flower of Prince Harry's mother Princess Diana, who died in a auto crash in Paris in 1997 when Harry was 12.
Kate Middleton has chosen Alexander McQueen once again! Lady Jane Fellowes, Diana's sister, also delivered a reading during the wedding.
The bride's father Thomas Markle also followed the wedding on television and voiced regret he was unable to attend, TMZ reported.
They shared that delight with onlookers who greeted them outside the church before heading off on a 30 minute carriage ride throughout Windsor before returning for their reception with the 600 invited guests.
The newly married Duke and Duchess of Sussex, Meghan Markle and Prince Harry, leaving Windsor Castle after their wedding to attend an evening reception at Frogmore House, hosted by the Prince of Wales Windsor, Britain, May 19, 2018. In one last departure from custom, the bride will give a speech. Harry and Meghan's royal wedding ceremony The ceremony began right on time at noon local time.