Tom Williams, chief operating officer of Airbus Commercial Aircraft, said: "In any scenario, Brexit has severe negative consequences for the United Kingdom aerospace industry and Airbus in particular".
Conservative MP for Pembrokeshire, where Airbus has a factory, and prominent Brexiteer Stephen Crabb tweeted: 'The enormous Airbus factory in North Wales is one of the jewels in the crown of United Kingdom manufacturing.
As a result Airbus is "carefully monitor [ing] any new investments in the United Kingdom and refrain from extending the United Kingdom suppliers/partners base".
"The Prime Minister has always said that nothing is agreed until everything is agreed and that no deal would be better than a bad deal, and I think it's essential as we enter the next phase of the negotiations that the European Union understands that and believes it".
"We don't want them to be affected by friction at the borders".
Airbus said last night the warning was not part of "project fear, but its "dawning reality".
She added the Government is working closely with companies to understand their concerns ahead of leaving the European Union and alongside industry will invest nearly £4 billion by 2026 to ensure the United Kingdom remains a "world leader" in civil aerospace.
Theresa May will listen to the concerns of the aerospace giant Airbus, Downing Street has said, after it confirmed it was considering cutting thousands of jobs in the United Kingdom in the absence of more detail about post-Brexit trading arrangements.
He added: "Put simply, a no-deal scenario directly threatens Airbus' future in the UK".
European Union nationals and their families who arrive between 30 March 2019 - after the United Kingdom leaves the European Union - and 31 December 2020 can stay on the same terms, but they will have to register if they choose to stay in the United Kingdom longer than three months.
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But the Foreign Secretary has branded the alarms as "the same old project fear stuff that we ignored two years ago".
Major manufacturers employing more than 20,000 people in the United Kingdom have spoken out about the potential impact of Brexit on key British industries. "Put simply, a No Deal scenario directly threatens Airbus" future in the United Kingdom'. This is a wake-up call.
"Without these, Airbus believes that the impacts on our United Kingdom operations could be significant".
Commenting Unite assistant general secretary with responsibility for aerospace Steve Turner said: "The realities of a "cliff edge" Brexit and its impact on jobs in manufacturing communities across the four nations of the United Kingdom are becoming closer by day".
And shadow Brexit secretary Sir Keir Starmer tweeted: "If proof was needed that the PM's Brexit red lines need to be abandoned (and fast), this is it".
He added: "They don't want some bog roll Brexit - soft, yielding and seemingly infinitely long".
"That is because they secretly want to reduce Brexit to an absurdity and then campaign to take the United Kingdom back in".
But organisers of the People's Vote march expect tens of thousands of people to show their support for a referendum on the final Brexit outcome. About one-and-a-half billion in tax revenue that will not go into the NHS.
Applicants need only to prove their identity, residency in the United Kingdom and not to be a serious criminal, with help available to try to ensure they got a positive outcome.