Seferi did a good job of surviving and Fury struggled to lay a glove on him in the second.
Over a dozen men engaged in a brutal brawl in the middle of Tyson Fury's fight against Albanian boxer Sefer Seferi, even prompting both fighters to pause to watch the mayhem at Manchester Arena, which hosted yesterday's fight night.
The fight in the stands was perhaps more entertaining than Fury's win. The caliber of opponents will keep on rising.
Seferi has fought much of his career at welterweight, but if the 37-year-old's 2016 effort against Manuel Charr is an indicator, Fury may have some mild trouble on his hands come showtime.
Fury has vowed to reclaim the world title and took his first step on that road against the over-matched Seferi, a former cruiserweight, who was withdrawn by his corner after taking some punishment in the fourth round.
"He took me a few rounds so I'm happy with it".
But Fury was disappointed by the attitude of 39-year-old Seferi, who was giving away more than 50lb and almost a foot of height difference on the night.
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Fury (26-0, 19 KOs) is next scheduled to fight on August 18 in Belfast against an opponent yet to be named.
"I'll be better next time". He needs to get the ring rust off.
Fury played to the crowd in the first round and looked a bit embarrassed when Seferi tried to rough up the former champion.
Fury in particular was clearly distracted by the fight between a group of thugs and the events have of course taken social media by storm.
Fury's English rival Anthony Joshua, the WBA-IBF-WBO champion, and American Deontay Wilder, the WBC champion, remain distant targets for Fury, whose priority now will be to build up some momentum against tougher opponents.
After twice pulling out of rematches with Klitschko, Fury then admitted problems with mental health, drinking too much and cocaine use before it was revealed he failed a drugs test for the banned steroid nandrolone in February 2015. He received his boxing licence in January after accepting a backdated two-year doping ban.