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Anderson's experience of having already won a grand slam semi-final may also be a factor here.
After two years of physical and mental struggles, Djokovic appears fit and confident and ready to try to add to his tally of 12 grand slam titles.
Second, his opponent will be two-time Wimbledon champion Rafael Nadal.
"It´s not good for me. Anything could happen", Nadal said.
Strokes of Genius is a world-class documentary capturing the historic 13-year rivalry between tennis icons Roger Federer and Rafael Nadal.
The pair have produced some of the greatest matches ever seen - which include memorable Grand Slam finals and career-defining victories.
Nadal and Djokovic will be meeting for the 52nd time in their career, with Djokovic leading their head-to-head 26-25. It's never easy playing a friend. It is always a big test.
The Serbian is playing his best tennis for two years as he appears to have finally put injuries and poor form behind him. That gave me really trouble. I tried to resist, maintaining focus. It wasn't easy to play obviously.
If you want to win Wimbledon, you need a bit of luck to go your way.
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The powerful Argentinian has won five of his 15 matches against Nadal but lost to the world number one at two of the last three slams.
"This photo says it all", wrote Juan Martin del Potro on his Instagram page.
"In some ways he deserves victory too", a gasping Nadal said after setting up a blockbuster semi-final with Novak Djokovic.
Moments later, Nadal's level dipped, allowing Juan Martín del Potro back into their quarter-final match.
Anderson or Isner to reach first SW19 final?
Opportunity knocks for both men here with a chance at a first Wimbledon final.
The more gusty conditions on No. 1 Court could make Federer's challenge against eighth-seeded Kevin Anderson more complicated.
"I said at the beginning of the tournament, getting through to the quarters was a big goal of mine", he said.
"I'm like, "You don't have to be sorry".
Ninth-seeded Isner has hit a tournament-high 135 aces on his way to reaching his first Wimbledon quarterfinal.
"My results were not up to the standard that I had before", said Djokovic after beating Kei Nishikori in the quarter-finals.