The singer, 76, is "gravely ill in Detroit", Roger Friedman reported on his Showbiz411 website.
The Queen of Soul is now surrounded by friends and family and they're asking for prayers and privacy at this time. They are now asking for prayers and privacy.
Dubbed the Queen of Soul, Franklin was diagnosed with pancreatic cancer in 2010 and has been battling the disease for the last eight years.
"Aretha Franklin has been ordered by her doctor to stay off the road and rest completely for at least the next two months", read a statement from her management at the time.
"Oh God. Aretha Franklin is trending for the reason I feared".
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Aretha began her career the 1950s, and released her first album "Songs Of Faith" in 1956.
The 76-year-old soul legend - who last performed at the Elton John AIDS Foundation party in NY in November - is said to be at her home in Detroit, where her loved ones have gathered to say their goodbyes.
Harry Hairston, an investigative reporter at the NBC station in Philadelphia, tweeted that he spoke with a close friend of Aretha Franklin.
She said: "I'm doing well generally, all test have come back good". Last year, after postponing a June concert at Ravinia due to health issues, Franklin returned in September for what one newspaper report called a "dazzling" performance.
Franklin was the first ever woman inducted into the Rock and Roll Hall of Fame in 1987 and topped Rolling Stone's Greatest Artists of All Time List. Aretha's name is trending on Twitter, with thousands of fans sending messages in tribute to the star.