Jack Sock and Kevin Anderson combined to deliver the sole triumph for their side, overcoming the world's second and third-ranked singles players 6-7 (5) 6-3 (10-6) to prevent an opening day shutout for Team Europe.
It pits two six-player teams against each other, one representing the best players from Europe, and one comprising of the best players from the rest of the world.
"Obviously I have a lot of confidence in the doubles court now", Sock said.
The two were playing doubles together for the first times in their careers at this weekend's Laver Cup in Chicago.
Team Europe had taken control of the match 7-1 after singles wins for Alexander Zverev and Roger Federer. "I think we still have to talk over it a little bit exactly maybe either who's going to take the lead or how do we play exactly". If points are 12-all on Day 3, a doubles set with a tiebreaker will decide the Laver Cup champion. It will be Roger Federer and Novak Djokovic, with 34 Grand Slam singles titles between them.
It was a first-time pairing for Anderson and Sock as well.
Canada's capital reeling after tornado hammers communities
Residents of the Ottawa region are facing widespread power outages and school closures after two tornadoes struck on Friday. Service was gradually being restored, but 50,000 in Ottawa alone still had no electricity late Sunday afternoon.
Team Europe needs another six points to retain the title it won in the inaugural competition past year heading into Sunday's final day, when three points are on the line in each of the four matches.
Novak Djokovic hit a great backhand victor on Sunday against Kevin Anderson at the Laver Cup.
An impressive return victor from Sock sealed the set 10-6, giving captain John McEnroe a little relief before day two.
Today's matches were worth two points each.
The world number two came from a set down to defeat big-serving American Isner 6-7 (5/7), 7-6 (8/6), 10/7 in an enthralling battle at Chicago's United Center.
Schwartzman had looked to threaten Europe's lead with a second-set comeback, and dug deep at 5-1 down in the last to level at 7-7, but Goffin remained calm on his first match point to cheers and hugs from his team-mates and captain Bjorn Borg.