Chen then turned her attention to her co-hosts, telling Eve, "You're the newest one at the table, but I feel like I've known you forever". Though she didn't directly address allegations against Moonves, she said, "I need to spend more time at home with my husband and our young son, so I've chose to leave 'The Talk'".
However, Chen is believed to be maintaining her role as host of "Big Brother".
CBS did not respond to multiple requests for comment.
CBS also released a statement in regards to Chen's announcement: "For eight seasons, Julie Chen has co-hosted The Talk with incredible energy, grace and professionalism".
Julie Chen is leaving "The Talk" a source close to the situation confirmed to Access.
Moonves has denied the allegations, but he agreed to donate $20 million from any severance benefits he may receive from CBS to the Me Too movement.
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As TV Insider previously reported, Chen has supported her husband throughout the scandal. Her exit comes after her husband, Leslie Moonves, was ousted as chairman-CEO of CBS Corp.
In her absence from The Talk, Chen's co-host haven't back away from addressing the controversy. The news of Chen's departure comes a little more than a week after her husband Les Moonves was sacked as CBS' CEO amid a score of sexual misconduct allegations, which he has denied.
"I fully support my husband and stand behind him and his statement", she tweeted in June. Sources at the network have said that she will continue to host the reality competition through the season finale which airs on September 26. I can only surmise they are surfacing now for the first time, decades later, as part of a concerted effort by others to destroy my name, my reputation, and my career. Sara Gilbert also shared her thoughts and saids she supports Chen "always", but added this is "an important time in our culture".
"He has always been a kind, decent and moral human being", Chen wrote in his defense this summer.
"I am taking a few days off from The Talk to be with my family", she said in a statement before the broadcast via Variety. For the first time, she used her full, married name when signing off.