Wozniacki's victory is bound to boost her confidence ahead of this month's season-ending WTA Finals in Singapore, where the 28-year-old is the defending champion.
It has come full circle for Wozniacki, who claimed her very first WTA title in Beijing in 2010.
In the first last week, she got to the Pan Pacific Open final in Tokyo.
"I was in a really good shape coming up to this tournament", Basilashvili said.
However, by winning the title, she will cut Simona Halep's lead at the top of the rankings to under 1000 points.
"I have been playing through pain in my back this whole week", said Osaka.
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Wozniacki produced a big hold for 4-1, saving three break points along the way, and to rub further salt in the wound Wang was duly broken to love in the next as the first set slipped away.
"She didn't give me any presents, it was tough", said Sevastova, who retired in May 2013 because of persistent injuries, only to return in January 2015. Having done everything, all of that, it's pretty unbelievable.
In the final match, Wozniacki held the opening set with a smash.
In another engrossing game that ebbed and flowed, del Potro saved two match points before failing to convert two break points of his own.
Sevastova, who is looking for her second title of the season, has never beaten Wozniacki in four previous meetings.
Caroline Wozniacki of Denmark said she was fulfilling childhood dreams as she won her second China Open crown in Beijing.