The New Jersey Department of Health said in a news release that "another medically fragile child" who had a confirmed case of adenovirus at the Wanaque Center for Nursing and Rehabilitation died Saturday night.
A total of 25 pediatric cases have been associated with the outbreak.
"This is a tragic situation, and our thoughts are with the families who are grieving right now", New Jersey Health Commissioner Dr. Shereef Elnahal said in a statement.
Similarly, the states' health department also ensures that it is working very closely with the facility to monitor the illness outbreak, and to ensure that all infection control measures are being followed.
Teams will also be sent to the Voorhees Pediatric Facility in the state, and the Children's Specialised Hospital with locations in Toms River and Mountainside.
Each of those who became ill had "severely compromised immune systems" before they got sick, and ranged in age from toddlers to young adults.
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The infection can cause other illnesses, including pneumonia, diarrhea and bronchitis, the department said. Another death Friday of a medically frail resident has not been confirmed by laboratory results as being linked to the illness, according to the NJDOH. The most recent outbreak of the illness at the facility, about 32 miles (50 km) northwest of New York City, was October 22.
Adenovirus can cause bronchitis, pneumonia and pink eye, but is especially risky to those with already compromised immune systems.
The highly contagious adenovirus poses little to risk to healthy people. The CDC is also investigating the outbreak.
Rowena Bautista, the administrator of the Wanaque Center for Nursing and Rehabilitation, said Thursday in a statement the community "feels a tremendous sense of loss".
The facility has since stopped admitting new residents as long as the outbreak is ongoing. Adenoviruses usually just cause mild illnesses.
The viruses typically spread from close personal contact such as touching or shaking hands, through the air by coughing and sneezing, and touching objects or surfaces that have the viruses on them before touching one's mouth, nose, or eyes.