Police rounded the protesters up in a Senate office building after they sat down and refused to budge.
Republican plans to confirm Kavanaugh could still be slightly complicated by the personal life of Montana Republican Sen.
Manchin released his statement declaring his support for Kavanaugh shortly after Collins finished her speech - and after Republicans had already secured enough votes to confirm the judge, meaning that Manchin would not be the deciding vote.
In a Quinnipiac poll issued on Monday, 48 percent of Americans said that Kavanaugh should not be confirmed to the Supreme Court, while 42 percent said he should be confirmed.
Activists protest in front of Sen. Murkowski and Democratic Sen.
Ms Ramirez said the nominee had exposed himself to her when they were both at Yale University, which he also denies.
Panthers: Grades for a close Week 5 win against the Giants
The speedster, 5-foot-11 and 195 pounds, showed some toughness by breaking three tackles to get into the end zone. Reid was the first player to kneel alongside Colin Kaepernick during the anthem in protest of social injustice.
A final vote on whether Judge Kavanaugh will join the nine-member panel could take place as soon as Saturday.
Earlier on Friday the Senate voted 51-49 to end debate on Mr Kavanaugh's nomination, setting up a final showdown on Saturday.
"We are going to have to do something to provide a check and balance, to protect the rule of law and to protect the legitimacy of one of our most important institutions", Nadler said in an interview with The New York Times on Friday. Several other undecided senators Republicans needed to move Kavanaugh's nomination forward said they felt the same way, forcing President Donald Trump to order an Federal Bureau of Investigation probe last Friday. Democrats were unconvinced by the bureau's findings, saying it was an incomplete investigation because several witnesses offered by Kavanaugh's accusers, among others, were not pursued. Susan Collins (R-Maine) when her seat is up for re-election in 2020.
President Donald Trump was quick to tweet his support of the nominee. It is a lovely thing to see - and they are not paid professional protesters who are handed expensive signs. "Big day for America!"
With divisive cases on abortion rights, immigration, transgender rights and business regulation headed for the court, Kavanaugh likely would give conservatives the upper hand.