After the 2015 season, Manning retired with the passing record and 539 touchdown passes, which is an all-time National Football League record.
Click on the video above to watch as Brees broke Peyton Manning's record with a stunning 62-yard touchdown pass to Tre'Quan Smith in the second quarter of the New Orleans Saints' Monday night win over the Washington Redskins.
He actually began the evening third on the all-time list and passed Brett Favre (71,838 yards) on Monday, as well.
Brees still needs 42 touchdown passes to surpass Manning's record of 539, something the Saints quarterback could achieve next season if he maintains his current level of play. As the Superdome crowd gave Brees a standing ovation, he removed his helmet and hugged his wife Brittany and their four children.
Brees was wearing a microphone for broadcaster ESPN and was recorded telling teammates, family members, and head coach Sean Payton how much he loved them.
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Rakeem Boyd also caught a 21-yard pass on a wheel route and Deon Stewart had a 16-yard reception on the possession. The Tide (6-0, 3-0) reeled off a 99-yard TD drive in just five plays after that fumble to take a 28-7 lead.
Drew Brees has become the NFL's all-time leader in yards passing - and he did it in style.
Brees exited the game at the two-minute warning in the fourth quarter. However, he has some competition from 40-year-old Patriots quarterback Tom Brady, who threw his 500th touchdown pass Thursday, while Favre is now in second place at 508. Brees now has 1545 yards and 10 touchdowns this season.
A second-round pick by the Chargers in 2001 after setting records at Purdue, Brees spent five seasons in San Diego as his career got off to a somewhat slow start.
"Also, let this serve as the congratulations for the touchdown record, because as you can see, I am very busy".