Once again, Lisa Murkowski was all alone. By consolidating Republican power, it would also make breaking camp and heading back towards the light that much more hard. His confirmation locks in a conservative majority in the Supreme Court, and Kavanaugh's judicial track record has raised fears about the future of reproductive rights, environmental regulations, workers' rights, and whether a president can be subpoenaed.
Kellyanne Conway, counsellor to the president, said on ABC's "This Week" that the focus should turn from Kavanaugh's combative testimony and towards his 12 years as a respected appeals court judge in Washington.
But in the wake of the unsuccessful bid to stop Kavanaugh's confirmation, the activists both on Capitol Hill and on social media began lashing out against Collins and her colleagues.
Instead of accepting Collins' reasoning, Dana Bash pressed the senator.and even tried to put words in her mouth. That was true with Kennedy on the bench, but he voted with the liberals in cases that preserved abortion rights and affirmative action, expanded LGBT rights and limited capital punishment. "I disagree that he's not the right guy at the right time".
The Senate is split 51-49 in favour of the Republicans and the vote will be largely along party lines. But Senate Republicans were satisfied with the investigation, and on Friday morning senators voted on cloture - that is, whether to limit debate on the nomination and require a final vote within 30 hours.
Kavanaugh, whose nomination was hit by multiple accusations of sexual misconduct against him from his past, replaces Kennedy who had announced his resignation early this year.
"'What neighborhood was it in?' 'I don't know.' 'Where's the house?' 'I don't know.' 'Upstairs, downstairs, where was it?' 'I don't know, but I had one beer.' 'That's the only thing I remember, '" Trump said.
It was a signature moment in Murkowski's political career, which has spanned almost two decades.
He predicted that Republicans would pick up Senate seats as a result. It ensures that Trump's influence, and that of a Republican stranglehold on power in Washington since the 2016 election, will endure long after current GOP leaders have left the scene.
Gary Neville fumes over Man United conduct regarding Mourinho leak
Jose Mourinho's position at the helm of Manchester United is not under immediate threat, senior figures at the club have said. But a significant section of fans back Mourinho over the board who they also think are culpable for the current problems.
The ideological tilt of the court hung in the balance, and a Republican president pushed hard with a conservative nominee that led to the most politically charged confirmation hearings in a generation, including intimate questions about the nominee's personal life.
Meanwhile, another woman, Deborah Ramirez who is married to a technology entrepreneur of Indian descent, Vikram Shah, alleged that while they were students at Yale, Kavanaugh had exposed his genitals in front of her at a party they had been drinking at.
Senators are expected to be there in force from 15:30 in the lead-up to the vote. The state's governor and lieutenant governor came out against Kavanaugh in late September, citing concerns that he posed a threat to health care protections and Native American tribal government, in additions to worries about the allegations he faced. "Is she mistaken?" Hirono said, adding that "anybody watching" her testimony would conclude she was being truthful about her story. "I have never sexually assaulted anyone".
Oddly, Ms Murkowski will also separately be counted for a "yes" vote. "But I don't want to suggest that something that I have chosen not to make public, not to discuss, that that becomes an issue point for others". I saw him rule in favor of criminal defendants who were unsympathetic. "Praying for them, praying for us and praying for the country". "I think we owed it him".
In statements reacting to Kavanaugh's confirmation, advocacy groups called the vote a "direct threat" to LGBTQ Americans. "And that's what they've become", he said.
But the Kavanaugh nomination has further poisoned already strained, partisan relations in the Senate. Just as fake news thrives on creating a false equivalence between its own lies and the truth, the forces of authoritarianism and division in U.S. political life will be strengthened if they can drag the court down to their own level.
As the Friday morning vote to advance Kavanaugh's nomination unfurled, the mood inside the Senate chamber was tense.
With tensions simmering, Pence got an earful from activists who booed and chanted "Vote them out!" as he walked to his motorcade.
Bash then went into some mumble jumble about a he-said-she-said scenario in which Collins ultimately decided Kavanaugh was innocent. The protesters, including two who interrupted a speech by Cornyn, were removed by gallery staff. For 26 minutes she explained how she arrived at her vote.