France manager Didier Deschamps has already called up Tottenham midfielder Moussa Sissoko as a replacement for Paul Pogba and now Arsenal striker Alexandre Lacazette has been added to the squad following the withdrawal of Anthony Martial.
The Frenchman last played for Les Bleus in November 2017, when he scored a brace in a friendly against Germany, though he was rather surprisingly left out of subsequent squads - including the side that won the World Cup in Russian Federation.
Martial has been in fine form recently, scoring six goals in his last seven games for United.
Deschamps said of the forward: 'He has incredible potential, but does not always show it regularly.
"What he is doing in Manchester now is closer to what he is able to do".
Anthony Martial played the full 90 minutes against Manchester City on Sunday meaning he picked up the injury during the derby.
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'He is still a young player, but one who, I hope, is seeing the importance he has taken in Manchester in recent weeks'.
Mendy was diagnosed with a left knee injury upon his arrival at Clairefontaine, and sent back to his club.
World champions France visit Netherlands in the Nations League on Friday before facing Uruguay in a friendly on November 20.
The Manchester United duo met up with the France squad on Monday morning but returned to Manchester for treatment after meeting with France's team doctor.
A draw with the Netherlands can guarantee the world champions a top spot in the group and a chance of contending for the Nations League title next June.