The physician, whose name is being withheld, isn't showing symptoms of the virus, officials at the medical center in Omaha, Nebraska said.
The 39-year-old physician was working at a missionary hospital in the Congo and treated a severely ill patient who subsequently tested positive for Ebola, Politico reported.
The American, the Nebraska release states, is not an official patient and is being taken privately to the medical center.
The individual will be monitored in a unit at the medical center that can safely quarantine individuals exposed to highly infectious diseases, such as Ebola.
Ebola can incubate for three weeks before symptoms emerge. Doctors will work with public health officials to monitor the patient and secure the area so other patients and members of the public will not be exposed to the deadly virus.
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And if we want to be there as far as possible until the end, we have to win games. He said: "You can lose two, and three, and four, five".
The monitoring will likely last up to two weeks.
The doctor had been providing medical assistance in the central African country, where over 300 people have died in the latest Ebola outbreak. Symptoms include fever, severe headache, diarrhea, and unexplained bleeding or bruising.
The Ebola virus spreads to people through direct contact with bodily fluids of an infected person.
"While this person isn't officially a patient, we will be honoring their request for privacy while they are being monitored here", Nebraska Medicine said.
The center where the physician is being held has experience treating Ebola patients and has a biocontainment unit to address symptoms if they develop. Nebraska Medical Center is one of a handful of places in the United States that has a dedicated biocontainment unit.
The Nebraska Medical Center's Biocontainment Unit is one of only several nationwide that was built and equipped for the specific objective of housing and monitoring individual who suffered possible exposure to a deadly disease, according to Wilson.