A host of pundits accused Ireland of lacking a Plan B in the wake of last weekend's 32-20 physical battering at the hands of England.
Rob Kearney comes in at full-back in place of Robbie Henshaw, who picked up a knock in training, while Chris Farrell will make his first Championship start as he replaces injured centre Garry Ringrose.
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Replacements: Sean Cronin, Dave Kilcoyne, Andrew Porter, Ultan Dillane, Josh van der Flier, John Cooney, Joey Carbery, Jordan Larmour.
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Meanwhile Chris Farrell partners Bundee Aki in midfield following a Dublin defeat that ended their hopes of back-to-back Grand Slams.
That injured trio have now been joined by Robbie Henshaw, who according to Schmidt has failed to shake off a dead leg. It's a knock on top of a knock.
"He just got a dead leg and it hasn't recovered sufficiently so we're just gonna have to forge ahead".
Maitland - who has four Heineken Champions Cup tries from five appearances this season - will form a familiar back three with Glasgow Warriors wing Tommy Seymour and full-back Stuart Hogg, with the trio combining for the 18th time for Scotland.
Toner's absence has exacerbated the prior lock losses of Iain Henderson to a finger problem and Tadhg Beirne to a knee complaint.