The former first lady went last, and got only a few words into her remarks about wearing out old Motown Records when she grew up on the South Side of Chicago before the audience drowned her out with applause.
Check out all the best celebrity reactions to the 2019 Grammy Awards below.
"We had to keep it on the low, especially because our forever first lady was here".
Flanked by two pianos ― one black, one white ― Keys delved into a cabaret-style medley of songs she wished she'd written, including Roberta Flack's "Killing Me Softly", Nat King Cole's "Unforgettable" and Lauren Hill's "Doo-Wop (That Thing)".
Thailand to free Bahraini footballer Hakeem Al-Araibi
The 25-year-old fears being returned to Bahrain where he believes he could face imprisonment and torture. He said the extradition case against Mr Al-Araibi was dropped by the Criminal Court on Monday afternoon.
The Grammys has frequently shut out hip-hop artists from its top prizes, despite rap's dominance as the biggest music genre in the United States. But it was female artists who dominated nominations in the top categories.
She won four Grammys in 2004, two in 2007 and Best R&B Album in 2013 for "Girl on Fire".
Check out the other 2019 Grammys performances by staying up to date on our ongoing coverage. Obama has sold out arenas on her massive worldwide book tour, where she has been interviewed on stage by Oprah Winfrey, Reese Witherspoon, Sarah Jessica Parker and former Obama senior adviser Valerie Jarrett, among others.