The Manchester City left-back posted his location on Instagram as being at Hong Kong global airport and when this was put to Guardiola, whose press conference was being broadcast on Sky Sports, the manager signalled his confusion by swearing.
Guardiola confirmed the 24-year-old is injured at present, his last appearance coming last month in the 1-0 League Cup semi final second leg win over Burton Albion.
"It was just joking with my uber driver I dont want no problems Pep", he said on Twitter.
"Yesterday he was in Barcelona".
Guardiola added: "Wow I didn't know that". "He needs to re-adapt, if you start training in two days you are fit, he has to handle the effort we are putting on him - he has to be careful".
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Benjamin Mendy's use of social media has frustrated Pep Guardiola.
Speaking in his, an incredulous Guardiola responded to questions regarding Mendy's whereabouts by admitting: "Hong Kong?"
"Wow", the City boss responded. F*** he is a lucky guy.
Meanwhile, Guardiola rejected suggestions that Liverpool are feeling the pressure after back-toback draws saw them drop below City at the top of the table. "He said he was going to Paris but Hong Kong - I don't know", said Guardiola in reference to where the Frenchman had gone after treatment in Spain.
"It will definitely not be okay if he is Hong Kong."