Sean O'Brien returns to the back row in place of Josh van der Flier, who limped off early in the win over Les Bleus.
The Irish boss, as expected, recalled Rob Kearney and Sean O'Brien while handing Tadhg Beirne his Six Nations debut.
Beirne is joined in the Ireland pack by Munster back-rowers Peter O'Mahony and CJ Stander.
Rory Best will lead the team out on his 64th and final Six Nations appearance with Cian Healy and Tadgh Furlong packing down alongside him in the front row.
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Ireland's centres and wingers are unchanged from last week's game with France, while Munster duo Niall Scannell and Dave Kilcoyne complete the replacements alongside Leinster's Andrew Porter and Jack Conan.
Jones said on Thursday that Wales were "starting to look a bit tired" after making "more tackles than anyone else in the tournament", and were facing an Ireland side "that seems to be peaking at the right time". "If it was me I'd be concentrating on playing Scotland", joked Gatland. I've got no comment on Eddie Jones talking about us. And that's been a really positive challenge for us throughout the Six Nations, and still try to get some cohesion.
"To say that was not his best performance, I know he'd agree with that", said Schmidt.
Wales are bidding for what would be a third Grand Slam under Gatland in what is his final Six Nations campaign before he steps down after the World Cup in Japan in November.