Naomi Osaka (JPN) waves to fans while leaving the court after being her fourth round match against Belinda Bencic (not pictured) in the BNP Paribas Open at the Indian Wells Tennis Garden. She began this year winning the Australian Open and moving to the top of the rankings.
Following Fed Cup and her Dubai title over Petra Kvitova, Bencic has now won her last 11 matches. "Honestly, at a time like this with that scoreline, I would usually feel very depressed and sad".
Osaka's loss ended a bad day for world number ones after the men's top player, Serb Novak Djokovic, fell 6-4 6-4 to Philipp Kohlschreiber.
The world No. 23 player will next battle against fifth seed player Karolina Pliskova for her place in the semi-finals.
Unseeded Czech teenager Marketa Vondrousova stunned world number two Simona Halep to reach the quarter-finals at Indian Wells.
On this unexpected victory, Bencic said, "I was really happy with the performance".
But there were no tears on Tuesday as Osaka said she was adjusting to being the world number one and always having a target on her back. "So just things worked out for me". Halep, who received treatment for blisters on her foot during the match, hit just six winners and piled up 36 unforced errors.
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The 21-year-old Japanese had a shaky start when she was broken early in the first set but quickly found her groove and broke the American four times and struck 29 winners to advance. Vondrousova, who beat 2018 runner-up Daria Kasatkina and former French Open victor Jelena Ostapenko on the way to the fourth round, will go for another big win when she faces sixth-seeded Elina Svitolina, who battled to a 7-6 (10/8), 5-7, 6-4 victory over Australian Ashleigh Barty.
Canada's Bianca Andreescu, 18, continued her remarkable season with a 7-5 6-2 win over China's Wang Qiang.
Ukrainian Elina Svitolina came from a break down in the third set to defeat Australian Ashleigh Barty 7-6 (8) 5-7 6-4 to reach the quarter-finals for the first time.
Kerber - the eighth seed - rallied from a set down to outlast qualifier Natalia Vikhlyantseva en route to the round of 16 on Monday.
"I was pretty determined this year", Williams said.
When asked in her on-court interview whether she is feeling more relaxed on the court, Osaka said has enjoyed playing tennis for a while now and is grateful for the opportunity to be back at the Premier Mandatory event in the Southern Californian desert.