Winger Joe Cokanasiga has been dropped from the England squad to face Scotland in the final game of the Six Nations on Saturday a week after his man-of-the-match performance in their thrashing of Italy.
Henry Slade is back in at outside centre with Manu Tuilagi shifted back to inside centre and Ben Te'o on the bench.
Despite scoring a double against Italy, Brad Shields has been assigned the role of a finisher with Mark Wilson starting at blindside flanker while Ben Moon replaces Ellis Genge at loosehead prop with the latter joining the reserves. A victory for Wales would secure a Grand Slam for Warren Gatland's men, while Ireland also has a chance of retaining the Six Nations title if it triumphs in Cardiff.
At London: England 38 (Jack Nowell, Tom Curry, Joe Launchbury, Jonny May, George Ford tries; Owen Farrell 4 con, pen; Ford con) Scotland 38 (Darcy Graham 2, Stuart McInally, Magnus Bradbury, Finn Russell, Sam Johnson tries; Finn Russell 3 con; Greig Laidlaw con).
"Joe's a good, young player and we're looking after him", Jones told reporters at England's training base in Bagshot, southwest of London, on Thursday. "We don't need to rush him, we'll bring him through carefully and he's got a long career ahead of him".
Ben Youngs will be making his 85th England appearance to surpass the national record for a scrum-half held by Danny Care.
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Tuilagi agreed a new two-year contract with Leicester this week and Jones added: 'Manu's future is looked after and we're really happy for him. "I don't know", Jones said. "The only thing we can control is how we play", he said. If Ireland win, so be it.
They did beat England in Edinburgh previous year when they outmuscled Jones's team at the ruck and the Australian said he expected a different scenario on Saturday after overseeing a massive improvement in that area, and in their discipline.
"It will be a fascinating finish to the Championship with three teams that can win it and we are playing against one of our most traditional foes in Scotland for the Calcutta Cup".
"Last year you could see at times, especially on the penalty count, that we became a bit too desperate and tried that bit too hard to get it back when that's not what we need to do".
'We've got a good plan in place for him [Cokanasiga].